Odei Barreñada University of Pittsburgh Postdoctoral Associate

204 Craft Ave Pittsburgh Pennsylvania 15213 United States

barrenadatalebo@upmc.edu 0000-0003-2908-8176 Q235034 Miguel Brieño-Enriquez University of Pittsburgh Assistant Professor

204 Craft Ave Pittsburgh Pennsylvania 15213 United States

brienoenriquezma@upmc.edu 0000-0002-8806-0918 Q235034 Odei Barreñada University of Pittsburgh Postdoctoral Associate

204 Craft Ave, Pittsburgh Pennsylvania 15213 United States

barrenadatalebo@upmc.edu 0000-0003-2908-8176 Q235034 Miguel Brieño-Enriquez University of Pittsburgh Assistant Professor

204 Craft Ave Pittsburgh Pennsylvania 15213 United States

brienoenriquezma@upmc.edu 0000-0002-8806-0918 Q235034 Female naked mole-rats (NMRs) are exceptionally long-lived (>40 years) and, unlike most mammals, show no decline in fertility with age. Within a colony, however, only a single dominant breeding female (the queen) reproduces, while the majority of females remain reproductively suppressed. If the queen is removed, subordinate females can transition into new breeders, restoring reproductive capacity. Recently, we demonstrated that oogenesis in NMRs occurs postnatally. Germ cell numbers increase markedly between postnatal day 5 (P5) and day 8 (P8), and primordial germ cells (PGCs) persist up to postnatal day 90 (P90), coexisting with germ cells at all stages of female differentiation. Naked Mole-Rat Heterocephalus glaber NMR Postnatal Oogenesis African Mole rat This information is released under the Creative Commons license – Attribution-NonCommercial - CC BY-NC (https://creativecommons.org/licenses/by-nc/4.0/). The consumer of these data ("Data User" herein) is required to cite it appropriately in any publication that results from its use. The Data User cannot use the material for commercial purposes. The Data User should realize that these data may be actively used by others for ongoing research and that coordination may be necessary to prevent duplicate publication. The Data User is urged to contact the authors of these data if any questions about methodology or results occur. Where appropriate, the Data User is encouraged to consider collaboration or co-authorship with the authors. The Data User should realize that misinterpretation of data may occur if used out of context of the original study. While substantial efforts are made to ensure the accuracy of data and associated documentation, complete accuracy of data sets cannot be guaranteed. All data are made available "as is." The Data User should be aware, however, that data are updated periodically and it is the responsibility of the Data User to check for new versions of the data. The data authors and the repository where these data were obtained shall not be liable for damages resulting from any use or misinterpretation of the data. Thank you. 2020 2025 Domain Eukaryota eukaryotes 2759 Kingdom Metazoa animals 33208 Phylum Chordata chordates 7711 Subphylum Craniata 89593 Superclass Sarcopterygii 8287 Class Mammalia mammals 40674 Superorder Euarchontoglires 314146 Order Rodentia rodents 9989 Suborder Hystricomorpha guinea pigs and others 33550 Family Bathyergidae African mole-rats 10167 Genus Heterocephalus 10180 Species Heterocephalus glaber naked mole-rat 10181 Miguel Brieño-Enriquez University of Pittsburgh Assistant Professor

204 Craft Ave Pittsburgh Pennsylvania 15213 United States

brienoenriquezma@upmc.edu 0000-0002-8806-0918 Q235034 Miguel Brieño-Enriquez University of Pittsburgh Assistant Professor

204 Craft Ave, PITTSBURGH Pennsylvania 15213 United States

brienoenriquezma@upmc.edu 0000-0002-8806-0918 Q235034 PI NICHD 1R56HD11164601A1 P90-NMR_3Mo-3B-s96 P90-NMR_3Mo-3B-s96.tif tif histology MABE_HG_P90-3B female 0 90 neonatal 1 ovary left P90-3B-s96 6 microns Zeiss AxioImager M2 microscope Zeiss AxioImager M2 microscope